The two crucial early steps in RNA synthesis by Hepatitis C virus 1 polymerase involve a dual role of residue 405 2
نویسندگان
چکیده
Nathalie Scrima, Célia Caillet-Saguy, Michel Ventura, Déborah Harrus, Thérèse Astier-Gin 3 and Stéphane Bressanelli 4 5 1 Laboratoire de Virologie Moléculaire et Structurale, CNRS UPR 3296, 1 avenue de la Terrasse, 6 91198 Gif-sur-Yvette cedex, France. 7 2 CNRS UMR 5234, SFR transBiomed, Université Bordeaux 2, 146 rue Léo Saignat, 33076 8 Bordeaux cedex, France. 9 § Present address: Unité de RMN des Biomolecules (CNRS UMR 3528), Institut Pasteur, 28 rue 10 du Docteur Roux, 75015 Paris, France. 11 * Present address: Centre de biochimie structurale, CNRS UMR 5048 INSERM UMR 1054, 29 12 rue de Navacelles, 34090 Montpellier Cedex, France. 13 # To whom correspondence should be addressed: [email protected] 14 15 Running title: Dual role of residue 405 in initiation by HCV-NS5B 16 17 18 19 20 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.00459-12 JVI Accepts, published online ahead of print on 24 April 2012
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